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KMID : 0389420100180020161
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Korean Journal of Stress Research
2010 Volume.18 No. 2 p.161 ~ p.165
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Changes of GABA Levels in Rat Brain Treated by Caffeine
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Oh Jin-Kyung
Jung Eun-Yee
Shim In-Sop
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Abstract
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Caffeine administration has been used to model sleep disruption. The purpose of this study was to examine the relation of caffeine with GABA (gamma amino butyric acid) levels in a translational caffeine-induced model of insomnia in rats. The change of GABA levels in caffeine-treated rat brain such as the cerebral cortex, hypothalamus, raphe nuclei (RN) andventral tegmental area (VTA) was investigated. GABA levels were significantly decreased with a time course by the administration of caffeine in the cerebral cortex and hypothalamus. There was a tendency that the GABA level in the RN, but not in the VTA was decreased. At high dose caffeine-treated rat, GABA levels were decreased in all the brain area. Especially, GABA levels were significantly decreased in the cerebral cortex and hypothalamus. These results suggest that the changes of GABA contents in caffeine-treated rat brain may be associated with many of the signs of insomnia or sleep disorders.
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KEYWORD
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Caffeine, GABA, Sleep
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